Jin learns that the mysteriously familar man is Sakamoto Ryoma, called the hero of the final days of the Tokugawa Shogunate, and wonders if Ryoma had been his unidentified patient at the hospital some 140 years into the future? Fearful of altering history he resists the efforts of Ogata Koan, head of the Western Medicine Institute' s entreaties for aid in treating the outbreak of cholera striking the city even as those he's come to care for begin to fall ill...